**Core Concept**
Negative pressure therapy, also known as vacuum-assisted closure, is a wound management technique that uses a controlled amount of subatmospheric pressure to promote wound healing. This method is based on the principle of enhancing blood flow and reducing edema in the affected area.

**Why the Correct Answer is Right**
Negative pressure therapy stimulates the production of growth factors, which promotes the migration and proliferation of fibroblasts and keratinocytes. This process accelerates the wound healing process by enhancing granulation tissue formation, collagen synthesis, and epithelialization. The controlled negative pressure also helps to reduce edema and promotes the removal of infectious materials and debris from the wound site.

**Why Each Wrong Option is Incorrect**
**Option A:** Negative pressure therapy is not typically used for the treatment of pressure ulcers, as it may exacerbate tissue damage in these patients.
**Option B:** Negative pressure therapy is not a suitable treatment for infected wounds, as it may worsen the infection and delay healing.
**Option C:** Negative pressure therapy is not a substitute for surgical debridement, as it may not be effective in removing necrotic tissue and other debris from the wound site.

**Clinical Pearl / High-Yield Fact**
Negative pressure therapy is most effective when used in conjunction with proper wound care, including debridement, dressing changes, and antibiotics if necessary. It is essential to monitor the wound site regularly to adjust the pressure and ensure optimal healing.

**Correct Answer: C. Chronic wounds**