**Core Concept**
Toxic epidermal necrolysis (TEN) is a severe skin condition characterized by widespread skin necrosis, typically triggered by medications. It is a form of severe cutaneous adverse reaction (SCAR) that can lead to significant morbidity and mortality.

**Why the Correct Answer is Right**
The correct answer is a medication known to cause TEN due to its potential to induce a severe immune-mediated reaction. This reaction involves the activation of cytotoxic T cells, leading to the release of pro-inflammatory cytokines and the subsequent necrosis of skin cells. The exact mechanism is not fully understood, but it is thought to be related to the drug's ability to bind to heat shock proteins, which can trigger an immune response.

**Why Each Wrong Option is Incorrect**
* **Option A:** A common antihypertensive medication, this drug is more likely to cause angioedema than TEN.
* **Option B:** A widely used antibiotic, this drug is associated with a range of skin reactions, but TEN is rare.
* **Option C:** A nonsteroidal anti-inflammatory drug (NSAID), this medication is more commonly linked to Stevens-Johnson syndrome than TEN.

**Clinical Pearl / High-Yield Fact**
When considering medications that can cause severe cutaneous adverse reactions, remember the acronym "Naranjo" which stands for N, A, R, A, N, J, O, which helps to identify potential culprits: Nonsteroidal, Antimicrobial, Radiocontrast, Anticonvulsant, Nonsteroidal, Antihistamine, Opioid.

**Correct Answer:** C.