Myoblasts of diaphragm develops from which somites –
**Core Concept:**
The question is testing our knowledge of embryonic development and somites, which are the primary germ layers and their contribution to various body structures, including skeletal muscles. In vertebrates, somites are segmental structures formed from the presomitic mesoderm in the vertebral column during embryonic development. These somites give rise to skeletal muscles, including the diaphragm.
**Why the Correct Answer is Right:**
Diastrophic myofibers of the diaphragm develop from the presomitic mesoderm (PM), which later gives rise to the somites. Somites further differentiate into myoblasts, which fuse to form myotubes, and subsequently, multinucleated myofibers. In this case, the diastrophic myofibers originate from the somites formed from the presomitic mesoderm.
**Why Each Wrong Option is Incorrect:**
A. Myoblasts of the diaphragm develop from somites formed from the neural crest cells, which is incorrect as the correct answer states they develop from presomitic mesoderm.
B. This option is incorrect as well, as the myoblasts of the diaphragm develop from presomitic mesoderm, not notochordal mesoderm.
C. Somites form from the paraxial mesoderm, not from lateral plate mesoderm as mentioned in this option.
D. This option is incorrect as well, as the myoblasts of the diaphragm develop from presomitic mesoderm, not from somites formed from the intermediate mesoderm.
**Clinical Pearl:**
Understanding the embryonic development of skeletal muscles, particularly the diaphragm, is crucial in understanding the formation of these muscles and their potential abnormalities. Knowledge of the correct developmental pathway can help in diagnosing congenital disorders like diaphragmatic hernia, which occurs due to the failure of the diaphragm development, particularly the formation of myotomes and somites.
**Correct Answer:**
The correct answer is option **D**. Diastrophic myofibers of the diaphragm develop from presomitic mesoderm, which further differentiates into somites and forms myotomes, contributing to the formation of the diaphragm.