Mutation of which of the following gene is most impoant in paroxysmal nocturnal hemaglobinuria?
Correct Answer: Glycosyl phosphatidyl inositol (GPI)
Description: Ans. is 'c Glycosyl phosphatidylinositol o PNH results from acquired mutation that inhibits the synthesis of Glycosyl-phosphatidyl-inositol (GPI). o The GPI linked proteins that are missing are membrane inhibitors of reactive lysis (MIRL; CD59), delay accelerating factor (DAF; CD55), C8 binding protein, urokinase plasminogen activator receptor, leukocyte alkaline phosphatase (LAP).
Category:
Pathology
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