**Core Concept**
Liddle's syndrome is a rare genetic disorder characterized by excessive sodium reabsorption in the distal convoluted tubule of the kidneys. This condition is caused by mutations in the genes encoding the ENaC (epithelial sodium channel) subunits.

**Why the Correct Answer is Right**
ENaC mutations lead to an overactive sodium channel, resulting in excessive sodium reabsorption. This causes an increase in blood pressure and hypokalemia due to potassium wasting. The overactive sodium channel is often resistant to feedback inhibition, leading to an increase in sodium reabsorption and a decrease in potassium secretion.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not associated with ENaC mutations.
* **Option B:** This option is not directly related to ENaC mutations, although it may be a consequence of the condition.
* **Option C:** This option is incorrect because it is not a direct consequence of ENaC mutations.

**Clinical Pearl / High-Yield Fact**
ENaC mutations can lead to Liddle's syndrome, which is characterized by hypertension, hypokalemia, and metabolic alkalosis.

**Correct Answer: C. Liddle's syndrome**