Multiple myleoma is characterized by all except –
**Core Concept**
Multiple myeloma is a clonal plasma cell disorder characterized by the accumulation of malignant plasma cells in the bone marrow, leading to bone destruction, anemia, and renal failure. The pathophysiology involves the proliferation of malignant plasma cells that produce monoclonal immunoglobulins (M-protein), leading to an imbalance in normal immunoglobulin production and function.
**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology and clinical features of multiple myeloma. The disease is characterized by the presence of M-protein, bone marrow plasmacytosis, and lytic bone lesions. The correct answer is a feature that is not typically associated with multiple myeloma.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because bone marrow plasmacytosis is a hallmark of multiple myeloma, where the bone marrow is infiltrated by malignant plasma cells.
**Option B:** This option is incorrect because M-protein production is a key feature of multiple myeloma, where the malignant plasma cells produce excessive amounts of a single type of immunoglobulin.
**Option C:** This option is incorrect because lytic bone lesions are a common feature of multiple myeloma, resulting from the destruction of bone tissue by the malignant plasma cells.
**Clinical Pearl / High-Yield Fact**
One important aspect of multiple myeloma is the presence of hypercalcemia, which is caused by the excessive breakdown of bone tissue. This can lead to symptoms such as renal failure, anemia, and neurological impairment.
**Correct Answer: D.**