Multiple myeloma-all are true except?
**Core Concept**
Multiple myeloma is a type of plasma cell malignancy characterized by the proliferation of malignant plasma cells in the bone marrow, leading to various systemic complications. The disease is often associated with the production of monoclonal immunoglobulins (M-protein) and can cause a range of symptoms and clinical manifestations.
**Why the Correct Answer is Right**
Dystrophic calcification is not a typical feature of multiple myeloma. Instead, the disease is often associated with lytic bone lesions, which can lead to various complications such as bone pain, pathologic fractures, and hypercalcemia. The correct answer, dystrophic calcification, is incorrect because it is not a characteristic feature of multiple myeloma.
**Why Each Wrong Option is Incorrect**
**Option A:** Proteinuria is a true feature of multiple myeloma, often due to the production of monoclonal light chains (Bence-Jones proteins) that can cause kidney damage and lead to proteinuria.
**Option B:** Visual disturbance is also a true feature of multiple myeloma, particularly due to the production of monoclonal immunoglobulins that can cause amyloidosis, leading to vision problems.
**Option C:** Bleeding is not a direct feature of multiple myeloma, but it can occur secondary to other complications such as anemia, thrombocytopenia, or the use of anticoagulant medications.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that multiple myeloma can present with a wide range of symptoms and clinical manifestations, including bone pain, anemia, hypercalcemia, and kidney damage. The disease often requires a multidisciplinary approach to diagnosis and treatment.
**β Correct Answer: D. Dystrophic calcification**