**Core Concept**
The treatment of multibacillary leprosy, especially in HIV-infected patients, requires a multidrug approach to effectively manage the disease and prevent resistance. **Multidrug therapy (MDT)** is the standard treatment for leprosy, combining multiple antibiotics to target **Mycobacterium leprae**.

**Why the Correct Answer is Right**
The World Health Organization (WHO) recommends a specific regimen for multibacillary leprosy, which typically includes **rifampicin**, **clofazimine**, and **dapsone**. This combination is effective against **M. leprae** and is used for 12 months. In HIV-infected patients, the treatment duration may be extended due to the compromised immune system.

**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because it does not specify a multidrug regimen.
**Option B:** Incorrect as it may not include all necessary drugs for multibacillary leprosy.
**Option D:** Incorrect because it is not the recommended treatment for multibacillary leprosy.

**Clinical Pearl / High-Yield Fact**
In treating leprosy, especially in immunocompromised patients like those with HIV, it's crucial to monitor for drug interactions and side effects, given the complexity of their treatment regimens.

**Correct Answer:** D. Rifampicin, clofazimine, and dapsone for 12 months.