**Core Concept**
Mullerian inhibiting substance (MIS), also known as anti-Mullerian hormone (AMH), is a glycoprotein hormone produced by the embryonic Sertoli cells in males. It plays a crucial role in the development and differentiation of the reproductive system by preventing the formation of Mullerian ducts in males.
**Why the Correct Answer is Right**
During embryonic development, the presence of MIS in males leads to the regression of Mullerian ducts, which would otherwise give rise to the female reproductive tract. This is mediated by the binding of MIS to its receptor, AMHR2, expressed on the surface of Mullerian duct cells. The binding of MIS to this receptor triggers a signaling cascade that ultimately results in the apoptosis of Mullerian duct cells, thereby preventing the formation of female reproductive structures.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect, as this option does not specify the correct cell type responsible for MIS production.
**Option B:** Incorrect, as this option does not accurately describe the role of MIS in reproductive development.
**Option C:** Incorrect, as this option suggests a different cell type responsible for MIS production.
**Clinical Pearl / High-Yield Fact**
Mullerian inhibiting substance is a useful marker for assessing ovarian reserve and follicular activity in females, with elevated levels indicating a reduced number of antral follicles.
**Correct Answer: C. Sertoli cells.**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.