Mucus plugs containing epithelial cell aggregations arranged as whorls of shed epithelium in the airway mucus plugs seen in bronchial asthma is known as:
Correct Answer: Curshmann spirals
Description: (Refer: Robbins Pathologic Basis of Disease, 8thedition, pg no: 691)
Histopathology of bronchial asthma
The mucus plugs contain whorls of shed epithelium, spiral shaped mucus plugs called Curshmannspirals
Numerous eosinophils.
Charcot-Leyden crystals - collections of crystalloid made upof an eosinophil lysophospholipase binding protein calledGalectin-10.
Overall thickening of airway wall.
Sub-basement membrane fibrosis (due to deposition oftype I and III collagen beneath the classic basementmembrane composed of type IV collagen and laminin).
Increased vascularity.
Increase in size of the submucosal glands; and
Mucous metaplasia of airway epithelial cells.
Hypertrophy and/or hyperplasia of the bronchial wall muscle.
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