(Refer: Robbins Pathologic Basis of Disease, 8thedition, pg no: 691) Histopathology of bronchial asthmaThe mucus plugs contain whorls of shed epithelium, spiral shaped mucus plugs called Curshmannspirals Numerous eosinophils. Charcot-Leyden crystals - collections of crystalloid made upof an eosinophil lysophospholipase binding protein calledGalectin-10. Overall thickening of airway wall. Sub-basement membrane fibrosis (due to deposition oftype I and III collagen beneath the classic basementmembrane composed of type IV collagen and laminin). Increased vascularity. Increase in size of the submucosal glands; and Mucous metaplasia of airway epithelial cells. Hypertrophy and/or hyperplasia of the bronchial wall muscle.