**Question:** Most significant indicator of fertility is -

A. Anti-Müllerian Hormone (AMH)
B. Follicle-Stimulating Hormone (FSH)
C. Luteinizing Hormone (LH)
D. Prolactin

**Core Concept:** Fertility indicators refer to laboratory tests that assess a woman's potential to conceive. The primary hormones involved in female fertility include Anti-Müllerian Hormone (AMH), Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), and Prolactin.

**Why the Correct Answer is Right:**

The correct answer is Anti-Müllerian Hormone (AMH) because it is directly involved in the process of follicle development and ovarian reserve. AMH is produced by granulosa cells within the ovaries and inhibits the development of unnecessary Müllerian duct remnants in females, thus indirectly reflecting the number of remaining follicles.

**Why Each Wrong Option is Incorrect:**

A. Follicle-Stimulating Hormone (FSH): FSH is essential for stimulating the growth of ovarian follicles but is not the primary indicator of ovarian reserve.
B. Luteinizing Hormone (LH): LH is involved in ovulation but is not the primary indicator of ovarian reserve.
C. Prolactin: Prolactin is a hormone related to lactation and does not play a significant role in fertility assessment.

**Why Each Wrong Option is Incorrect:**

A. Prolactin: Prolactin is a hormone related to lactation and does not play a significant role in fertility assessment.
B. Luteinizing Hormone (LH): LH is involved in ovulation but is not the primary indicator of ovarian reserve.
C. Follicle-Stimulating Hormone (FSH): FSH is essential for stimulating the growth of ovarian follicles but is not the primary indicator of ovarian reserve.

**Clinical Pearl:** A reliable indicator of fertility is the combination of Anti-Müllerian Hormone (AMH) and Inhibin B. These biomarkers together provide a comprehensive assessment of the ovarian reserve and can help predict a woman's chances of conceiving naturally or after fertility treatments.