Most pathognomic sign of irreversible cell injury
Correct Answer: Amorphous densities in mitochondria
Description: Ref Robbins 9/e p50 Mitochondrial Damage and Dysfunction Mitochondria may be viewed as "mini-factories" that produce life-sustaining energy in the form of ATP. Not surprisingly, therefore, they are also critical players in cell injury and death (Fig. 1-16). Mitochondria are sensitive to many types of injurious stimuli, including hypoxia, chemi- cal toxins, and radiation. Mitochondrial damage may result in several biochemical abnormalities: * Failure of oxidative phosphorylation leads to progres- sive depletion of ATP, culminating in necrosis of the cell, as described earlier. * Abnormal oxidative phosphorylation also leads to the formation of reactive oxygen species, which have many deleterious effects, described below. * Damage to mitochondria is often associated with the formation of a high-conductance channel in the mito- chondrial membrane, called the mitochondrial permea- bility transition pore. The opening of this channel leads to the loss of mitochondrial membrane potentialand pH changes, fuher compromising oxidative phosphorylation. * The mitochondria also contain several proteins that, when released into the cytoplasm, tell the cell there is internal injury and activate a pathway of apoptosis, dis- cussed later.
Category:
Anatomy
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now