Most of the ALLs have –
Correct Answer: B–cell origin
Description: Acute lymphoblastic leukaemia/lymphoma
Acute lymphoblastic leukaemia (ALL) encompasses a group of neoplasms composed of immature, precursor B (Pre-B) or T (Pre-T) lymphocytes referred to as lymphoblast.
The majority (85%) of all ALLs are precursor -cell tumors that typically manifest as childhood "leukaemia" with extensive bone marrow and variable peripheral blood involvement.
The less common precursor T-cell ALLs tend to present in adolescent males as "lymphomas" often with thymic involvement.
The peak incidence of Pre -cell ALL is evident between 3-5 years and ALL is the most common childhood cancer.
Pre T-cell ALL occurs in adolescent male.
Morphology of tumor cell (lymphoblast)
Having scant cytoplasm and nuclei somewhat larger than those of small lymphocytes.
The nuclear chromatin is delicate and finely stippled and nucleoli are either absent or inconspicuous.
Contain cytoplasmic aggregates of periodic acid Schiff (PAS) positive material.
Category:
Pediatrics
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now