**Question:** Most common ocular feature in Reiter Syndrome is

A. Conjunctivitis
B. Uveitis
C. Keratitis
D. Retinitis

**Correct Answer:** C. Keratitis

**Core Concept:** Reiter Syndrome, also known as Reiter's Disease or Reiter's Triad, is a rare but severe form of reactive arthritis that occurs as a complication of sexually transmitted infections like Chlamydia and gonorrhea. It presents with a triad of symptoms: arthritis, urethritis, and conjunctivitis.

**Why the Correct Answer is Right:** The most common ocular feature in Reiter Syndrome is Keratitis (inflammation of the cornea). This is due to the following considerations:

1. **Pathophysiology:** Reiter Syndrome is primarily an autoimmune response triggered by infections like Chlamydia and gonorrhea. Inflammation and tissue damage in the affected areas, including the eye, lead to various ocular manifestations.
2. **Keratitis:** This ocular manifestation is characterized by inflammation and swelling of the cornea, which can cause pain, redness, and photophobia. It is a significant concern as it can lead to corneal ulceration, perforation, and even blindness if not properly managed.

**Why Each Wrong Option is Incorrect:**

A. **Conjunctivitis (Option A):** While conjunctivitis is a common ocular manifestation in Reiter Syndrome, it is less severe and does not directly cause corneal involvement, which is the case in keratitis (Option C).

B. **Uveitis (Option B):** Uveitis refers to inflammation of the uvea (iris, ciliary body, and choroid). Although uveitis is a common feature in Reiter Syndrome, keratitis is more severe and directly affects the cornea, making keratitis the correct answer.

D. **Retinitis (Option D):** Retinitis refers to inflammation of the retina. While retinitis is a potential manifestation of Reiter Syndrome, keratitis is the more severe ocular feature affecting the cornea, making it the correct answer.

**Clinical Pearl:** Early recognition and management of keratitis in patients with Reiter Syndrome are crucial to prevent severe complications and preserve vision. Patients should be referred to an ophthalmologist and treated with appropriate antibiotics, corticosteroids, and immunosuppressive agents as needed, depending on the extent of keratitis and other systemic manifestations.