**Question:** Most common complication of pseudocyst of pancreas is

A. Pancreatic abscess
B. Peripancreatic fluid collection
C. Pancreatic rupture
D. Splenic rupture

**Core Concept:** Pseudocysts are fluid-filled collections within the abdomen that develop as a result of pancreatic inflammation or injury. They are usually caused by chronic pancreatitis and can be associated with other serious complications.

**Why the Correct Answer is Right:** The most common complication of a pseudocyst of the pancreas is pancreatic rupture (option C). A pseudocyst can rupture into surrounding structures or organs, leading to life-threatening hemorrhage, contamination of the peritoneal cavity, and subsequent infection (peritonitis).

**Why Each Wrong Option is Incorrect:**

A. Pancreatic abscess (option A): A pancreatic abscess is a localized infection within the pancreas, whereas a pseudocyst is a fluid-filled collection outside the pancreas, making option A incorrect.
B. Peripancreatic fluid collection (option B): Although a pseudocyst may lead to peripancreatic fluid collection, the specific complication mentioned in the question is pancreatic rupture, which is different and more severe than a mere fluid collection.
D. Splenic rupture (option D): Pseudocysts can rupture into adjacent organs, but splenic rupture is not a direct complication of a pseudocyst, making option D incorrect.

**Clinical Pearl:** The distinction between a pseudocyst and an abscess is crucial as it influences management strategies. A pancreatic abscess requires internal drainage, while a pseudocyst typically requires external drainage via percutaneous catheter placement or surgery.

**Correct Answer:** C. Pancreatic rupture