**Question:** Most common complication of celiac plexus block:

A. Bleeding
B. Infection
C. Hypotension
D. Hypoglycemia

**Core Concept:** Celiac plexus blocks are regional anesthesia techniques used for managing abdominal pain, particularly in patients with pancreatic or gastrointestinal cancer. The celiac plexus is a group of nerves located in the retroperitoneum, which innervates the stomach, duodenum, and part of the jejunum. The block is performed to relieve pain originating from these organs.

**Why the Correct Answer is Right:**

The most common complication of a celiac plexus block is **hypotension** (Option C). This occurs due to the blockage of sympathetic outflow from the celiac plexus, leading to decreased peripheral vascular resistance, decreased cardiac output, and decreased blood pressure. This is a direct consequence of the block and is a known complication of the procedure.

**Why Each Wrong Option is Incorrect:**

A. **Bleeding** (Option A) is a rare complication of celiac plexus block. The block does not involve direct vascular injury, so bleeding is less likely than hypotension or infection.

B. **Infection** (Option B) is rarely associated with celiac plexus blocks. The procedure is performed under sterile conditions, and the risk of infection is low.

D. **Hypoglycemia** (Option D) is less likely than hypotension. The block does not involve direct interference with glucose homeostasis, whereas the risk of hypotension is a direct consequence of the block.

**Clinical Pearl:**

While celiac plexus blocks are generally safe, the choice of local anesthetic, needle placement, and technique used must be carefully considered to minimize complications. Hypotension is a known but manageable complication, often transient and responsive to vasopressors. The procedure should be performed by an experienced anesthesiologist or pain specialist.