Most common Cause of fracture in hemophilic ahropathy
Correct Answer: Osteoporosis & restrictive joint movement
Description: Hemophilic ahropathy is a disabling condition characterized by joint impairment, chronic pain, and reduced quality of life . Recent evidence indicates that intra-aicular inflammation and angiogenesis may be pivotal processes in the pathogenic cascade of hemophilic ahropathy . Joint bleeding ors iron release from hemoglobin, thus inducing a chronic inflammatory process mediated by cytokines and pro-angiogenic factors and consequently leading to progressive synol pannus growth and aicular cailage damage . Spontaneous joint bleeding and repeated hemahroses lead to hemophilic ahropathy--a debilitating disease with a significant negative impact on mobility and quality of life. Iron, cytokines, and angiogenic growth factors play a pivotal role in the onset of the inflammatory process that involves the synol tissue, aicular cailage, and subchondral bone, with early damages and molecular changes determining the perpetuation of a chronic inflammatory condition. Synovitis is one of the earliest complications of hemahrosis, and is characterized by synol hyperophy, migration of inflammatory cells, and a high degree of neo-angiogenesis with subsequent bleeding. Ref - pubmed.com <a href="
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now