Most common association in MEN 1 is –
Correct Answer: Gastrinoma
Description: Ans. is 'a' i.e. Gastrinoma "Gastrinomas are the most common pancreatic islet tumors in MEN1 patients, accounting for over half of all pancreatic islet tumors in these patients." - Clinical Neuroendocrinology p. 342"The most common islet neoplasm in MEN 1 secret pancreatic polypeptide & is nonfunctional, while gastrinoma is a most frequent functional tumor." - Essentials of General Surgery"The most common functional islet cell tumor in MEN1 is gastrinoma " - Oncology: An Evidence-Based Approach MEN-1(Wermer syndrome)o It involves primarily three glands1) Parathyroid (parathyroid hyperplasia/adenoma): Most common manifestation.2) Pituitary: Prolactinoma is the most common type of pituitary tumor in MEN-I.3) Pancreas: There is islet cell hyperplasia/adenoma.o Less common findings are pheochromocytoma, foregut carcinoid, lipomas and dermal angiofibroma
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