**Question:** Mortality of rabies is -

A. Zero
B. High
C. Low
D. Moderate

**Core Concept:**
Rabies is a viral infection caused by the Lyssavirus, primarily affecting the central nervous system (CNS). It is transmitted through the saliva of infected animals, particularly dogs, bats, and raccoons. Once the virus enters the body, it progresses from the peripheral nervous system to the CNS, leading to a characteristic clinical syndrome known as "hydrocephalic rabies" or "furuncle of the brain." The mortality rate is determined by the stage at which the patient seeks medical attention and the effectiveness of post-exposure prophylaxis (PEP).

**Why the Correct Answer is Right:**
The correct answer is **Zero**, as the implementation of proper post-exposure prophylaxis (PEP) can effectively prevent rabies in humans. PEP involves a series of vaccinations, anti-rabies immunoglobulins, and wound cleansing. When administered within 24-48 hours after exposure, PEP can effectively prevent the virus from entering the CNS, thereby reducing the risk of rabies.

**Why Each Wrong Option is Incorrect:**

A. High: This is incorrect because timely PEP can significantly reduce the risk of rabies development.
B. Low: This is incorrect as the mortality rate can be significantly reduced with proper PEP.
C. Moderate: This is incorrect because the mortality rate can be significantly reduced with proper PEP, as explained above.

**Clinical Pearl:**
Ensuring awareness about the availability and timely administration of PEP is crucial in preventing rabies mortality. In regions where rabies is prevalent, it is essential for healthcare professionals to educate patients and the public about the importance of PEP following animal bite exposure. Furthermore, healthcare facilities should maintain a stock of necessary vaccines and immunoglobulins to promptly initiate PEP when required.