**Core Concept**
In breast cancer, adjuvant radiotherapy is a treatment strategy used to eliminate residual microscopic disease after surgery, thereby reducing the risk of local recurrence and improving survival outcomes. The decision to administer radiotherapy depends on various factors, including the tumor's histological characteristics, lymph node involvement, and surgical margins.

**Why the Correct Answer is Right**
Adjuvant radiotherapy is generally recommended for patients with high-risk features, such as:
- Tumor size greater than 5 cm
- Positive lymph nodes (≥ 4 positive nodes)
- Invasive lobular carcinoma
- Inflammatory breast cancer
- Close or positive margins
- Estrogen receptor (ER) negative or progesterone receptor (PR) negative tumors
- HER2-positive tumors with high Ki-67 levels
Adjuvant radiotherapy can help eliminate microscopic disease, reduce the risk of local recurrence, and improve overall survival.

**Why Each Wrong Option is Incorrect**
**Option A:** Not a correct answer as it is a common indication for adjuvant radiotherapy.
**Option B:** Not a correct answer as it is a common indication for adjuvant radiotherapy.
**Option D:** Not a correct answer as it is a common indication for adjuvant radiotherapy.

**Clinical Pearl / High-Yield Fact**
When considering adjuvant radiotherapy in breast cancer, it's essential to remember the "Van Nuys criteria," which help guide the decision-making process. The criteria include tumor size, margin status, histological grade, and the presence of lymphovascular invasion.

**Correct Answer: D**