Vitamin K is involved in post translation modification of which of the following aminoacids?
## **Core Concept**
Vitamin K plays a crucial role in the post-translational modification of certain proteins, specifically in the process of **gamma-carboxylation** of glutamic acid residues. This modification is essential for the biological activity of these proteins, particularly in blood clotting.
## **Why the Correct Answer is Right**
The correct answer, **Glutamic acid**, is the amino acid that undergoes gamma-carboxylation in a reaction that requires vitamin K as a cofactor. This process converts glutamic acid residues into **gamma-carboxyglutamic acid (Gla)**, which is critical for the calcium-binding properties of clotting factors such as prothrombin and other vitamin K-dependent proteins. The enzyme responsible for this modification is **gamma-glutamyl carboxylase**. Vitamin K acts as a cofactor for this enzyme, and its reduced form (vitamin KH2) is essential for the carboxylation reaction.
## **Why Each Wrong Option is Incorrect**
- **Option A:** Not applicable as the option is blank.
- **Option B:** Not applicable as the option is blank.
- **Option C:** Not applicable as the option is blank.
- **Option D:** Not applicable as the option is blank.
## **Clinical Pearl / High-Yield Fact**
A key clinical point to remember is that **warfarin**, an anticoagulant, works by inhibiting the synthesis of vitamin K-dependent clotting factors. It does so by blocking the enzyme **vitamin K epoxide reductase**, which is necessary for the recycling of vitamin K in the liver. This results in the production of inactive clotting factors, which is the therapeutic basis for warfarin's anticoagulant effect.
## **Correct Answer:** . Glutamic acid