**Core Concept**
Mifepristone, a progesterone receptor antagonist, is used off-label for the treatment of uterine fibroids. Its mechanism of action involves blocking the progesterone receptors, leading to a decrease in fibroid size and reduction in symptoms.

**Why the Correct Answer is Right**
Mifepristone's use in uterine fibroids is associated with several concerns due to its mechanism of action. These concerns include **amenorrhea (loss of menstrual cycle)**, **cushingoid symptoms (due to increased cortisol levels)**, and **potential impact on bone density**. Additionally, mifepristone can cause **uterine contractions and potentially lead to miscarriage or preterm labor** in pregnant patients.

**Why Each Wrong Option is Incorrect**
**Option A:** This option should be a concern while using mifepristone for uterine fibroids.
**Option B:** This option should be a concern while using mifepristone for uterine fibroids.
**Option C:** This option should be a concern while using mifepristone for uterine fibroids.

**Clinical Pearl / High-Yield Fact**
It is essential to screen patients for pregnancy before starting mifepristone treatment for uterine fibroids, as it can cause uterine contractions and potentially lead to miscarriage or preterm labor.

**Correct Answer: D.**