Deficiency of which of the following micronutrient results in Menkes syndrome
**Core Concept**
Menkes syndrome is a genetic disorder characterized by **copper** deficiency, leading to impaired connective tissue growth and development. The underlying principle involves the role of **copper** in various enzymatic reactions, including those related to **connective tissue** health. **Copper** plays a crucial role in the functioning of enzymes such as lysyl oxidase.
**Why the Correct Answer is Right**
The correct answer is related to **copper** because Menkes syndrome is caused by mutations in the **ATP7A** gene, which encodes a **copper**-transporting ATPase. This mutation impairs the transport of **copper** across the intestinal epithelium and into the bloodstream, resulting in systemic **copper** deficiency. As a result, **copper**-dependent enzymes are unable to function properly.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not relate to the specific micronutrient deficiency causing Menkes syndrome.
**Option B:** Similarly, this option is incorrect as it is not associated with Menkes syndrome.
**Option C:** This option is also incorrect as the condition is not related to the mentioned micronutrient.
**Clinical Pearl / High-Yield Fact**
Menkes syndrome is a rare, X-linked recessive disorder, and **copper** supplementation is often used as a treatment to manage the condition. Early diagnosis is crucial to prevent long-term damage.
**Correct Answer:** D. Copper