Microangiopathic hemolytic anaemia is seen in all of the following diseases except aEUR’
Correct Answer: Antiphosphplipid antibody syndrome
Description: Antiphospholipid antibody syndrome Metallic cardiac valves do not cause microangiopathic hemolytic anemia. Don't mix microangiopathic hemolytic anemia with fragmentation syndrome. They are two separate entities, according to most standard text in hematology. Fragmentation syndrome Red cells when subjected to mechanical trauma may undergo .fragmentation in circulation. These fragment cells have shapes like triangular cells, helmet cells and are known as schistiocytes and are easily made out in a well made peripheral blood, film. Schistiocytes are the hallmark of diagnosis of this group of hemolytic anemia. Fragmentation of the red cell can occur either in large vessels or small vessels of capillaries and aerioles. Microangiopathic hemolytic Anemia When fragmentation occurs in small vessels of capillaries and aerioles due to the presence of thrombotic lesions, it is called microangiopathic hemolytic anemia. Microangiopathic hemolytic anemia is characterized by hemolytic anemia due to red cell .fragmentation. There is associated small vessel disease of capillaries and aerioles with thrombotic lesions. As the red cells pass through these microthrombi, red cells get attached to them and pa of RBC's get .fragmented by high shear forces. But the problem is that Harrison does not make any distinction between these two:? - It is clearly mentioned in Harrison table 101-6 page 658 that microangiopathic hemolytic anaemia occurs in prosthetic hea walls. - C.M.D.T also shares same views. We may have to go against Harrison in this case (may be they might have loosely used the term microangiopathic hemolytic anemia).
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