MIC-2- Marker of
**Core Concept**
MIC-2 is a cell surface glycoprotein that belongs to the CD family. It is expressed on the surface of certain T-cell lymphoblasts and plays a crucial role in the differentiation of T-cells. MIC-2 is used as a marker for identifying Ewing's sarcoma, a type of bone cancer.
**Why the Correct Answer is Right**
MIC-2 is expressed on the surface of Ewing's sarcoma cells, making it a useful marker for diagnosing this condition. The MIC-2 gene is involved in the regulation of cell growth and differentiation, and its expression is often upregulated in Ewing's sarcoma cells. The use of MIC-2 as a marker is based on its ability to detect the presence of Ewing's sarcoma cells in tissue samples.
**Why Each Wrong Option is Incorrect**
**Option A:** MIC-2 is not typically expressed on the surface of B-cell lymphoblasts, making it an incorrect choice for B-cell markers.
**Option B:** While MIC-2 is a cell surface glycoprotein, it is not typically used as a marker for identifying other types of bone cancers, such as osteosarcoma.
**Option C:** MIC-2 is not a marker for identifying other types of T-cell lymphomas, such as T-cell acute lymphoblastic leukemia.
**Clinical Pearl / High-Yield Fact**
MIC-2 is a useful marker for identifying Ewing's sarcoma, but it is not specific for this condition. A combination of MIC-2 expression with other diagnostic markers and clinical features is typically used to confirm the diagnosis of Ewing's sarcoma.
**Correct Answer: D. Ewing's sarcoma**