**Core Concept**
Domperidone and metoclopramide are both dopamine receptor antagonists used to enhance gastrointestinal motility. However, they differ in their pharmacokinetic properties and side effect profiles.

**Why the Correct Answer is Right**
Domperidone is a peripherally selective dopamine receptor antagonist, primarily affecting the gastrointestinal tract, whereas metoclopramide has central nervous system (CNS) activity. This peripheral selectivity of domperidone reduces the risk of CNS side effects, such as extrapyramidal reactions, which are more common with metoclopramide.

**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because domperidone does have a longer half-life compared to metoclopramide, allowing for less frequent dosing.
**Option B:** Incorrect because domperidone is indeed less likely to cause CNS side effects, such as sedation and confusion, compared to metoclopramide.
**Option C:** Incorrect because domperidone is actually more likely to cause QT interval prolongation than metoclopramide, although this is not a primary advantage.

**Clinical Pearl / High-Yield Fact**
When choosing between domperidone and metoclopramide, consider the patient's risk of CNS side effects, as domperidone's peripheral selectivity makes it a safer option in this regard.

**Correct Answer:** C.