Methylation of deoxyuridylate to thymidylate involve one carbon metabolism. Cofactor in one carbon metabolism is:
Correct Answer: Folic acid
Description: FH4 is an intermediate in reactions involving the transfer of one-carbon units from a donor to an acceptor. One-carbon units enter the folate pool principally the serine hydroxymethyltransferase reaction which requires pyridoxal phosphate as cofactor. The most impoant clinically is the methylation of deoxyuridylate to thymidylate, catalyzed by the enzyme thymidylate synthase. This reaction is an essential step in the synthesis of DNA. Metabolic Systems Requiring Folic Acid Coenzymes: Serine ? glycine Thymidylate synthesis Histidine catabolism Methionine synthesis Purine synthesis Ref: Green R. (2010). Chapter 41. Folate, Cobalamin, and Megaloblastic Anemias. In J.T. Prchal, K. Kaushansky, M.A. Lichtman, T.J. Kipps, U. Seligsohn (Eds), Williams Hematology, 8e.
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now