Pharmacology Methicillin resistant staphylococci do not respond to b-lactam antibiotics because: A They produce a b-lactamase which destroys methicillin and related drugs B They elaborate an amidase which destroys methicillin and related drugs C They have acquired penicillin binding protein which has low affinity for b-lactam antibiotics D They are less permeable to b-lactam antibiotics 💡 Explanation Methicillin resistant staphylococci do not respond to b-lactam antibiotics because: ✓ Correct Answer: C. They have acquired penicillin binding protein which has low affinity for b-lactam antibiotics