Methicillin resistant staphylococci do not respond to b-lactam antibiotics because:

A. They produce a b-lactamase which destroys methicillin and related drugs

B. They elaborate an amidase which destroys methicillin and related drugs

C. They have acquired penicillin binding protein which has low affinity for b-lactam antibiotics

D. They are less permeable to b-lactam antibiotics

Correct Answer: They have acquired penicillin binding protein which has low affinity for b-lactam antibiotics

Description: (Ref: KDT 6/e p700) Resistance to most penicillins is due to elaboration of beta-lactamase. Methicillin is most resistant penicilling to b-lactamase. Staphylococcus aureus develops resistance to methicillins by acquisition of altered pencillin binding proteins.

Category: Pharmacology

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