Pharmacology Methicillin-resistant staphylococci do not respond to β–lactam antibiotics because : A They produce a β–lactamase which destroys methicillin and related drugs B They elaborate an amidase which destroys methicillin and related drugs C They have acquired penicillin binding protein which has low affinity for β-lactam antibiotics D They are less permeable to β-lactam antibiotics 💡 Explanation Methicillin-resistant staphylococci do not respond to β–lactam antibiotics because : ✓ Correct Answer: C. They have acquired penicillin binding protein which has low affinity for β-lactam antibiotics