Pharmacology Methicillin-resistant staphylococci do not respond to β-lactam antibiotics because: A They produce a b-lactamase which destroys methicillin and related drugs. B They elaborate an amidase which destroys methicillin and related drugs. C They are less permeable to b-lactam antibiotics. D None of the above 💡 Explanation Methicillin-resistant staphylococci do not respond to β-lactam antibiotics because: ✓ Correct Answer: B. They elaborate an amidase which destroys methicillin and related drugs.