Medical MCQ-Metformin causes I severe, sometimes life-threatening side effect of lactic acidosis. All of the following factors increase the risk of lactic acidosis except:

Metformin causes I severe, sometimes life-threatening side effect of lactic acidosis. All of the following factors increase the risk of lactic acidosis except:

Advanced age

Smoking

Liver dysfunction

Renal failure

Question Category:

Pharmacology

Correct Answer:

Smoking

Description:

Ans: B. Smoking(Ref Goodman Gilman 12/e p1259; Katzung I 3/e p736-737, 12/e p75)Smoking does not increase lactic acidosis risk in patients taking metformin.Lactic acidosis & metformin:Metformin use in patients with concurrent conditions with poor tissue perfusion (sepsis, myocardial infarction, CHF & enal failure).Decreased GFR - Increases plasma metformin levels - By reducing drug clearance from circulation.Metformin - ContraindicationsSevere pulmonary disease.Decompensated hea failure.Severe liver diseaseChronic alcohol abuse.Renal disease.Conditions predisposing to tissue anoxia (e.g., chronic cardiopulmonary dysfunction) - Due to increased lactic acidosis risk.

Previous MCQ

Next MCQ

Get More

Subject Mock Tests

Try practicing mock tests with over 200,000 questions from various medical subjects.

Attempt a mock test now

Mock Exam

Attempt an exam of 100 questions randomly chosen from all subjects.

Coming Soon