**Core Concept**
The question tests knowledge of **cardiac myxoma**, a type of benign tumor that occurs in the heart. Cardiac myxomas are the most common type of primary heart tumor and have distinct characteristics. They are typically found in the **atria**, with a preference for the left side.

**Why the Correct Answer is Right**
Cardiac myxomas are indeed more common in females, and they most frequently occur in the **left atrium**. The left atrium is the chamber of the heart where oxygenated blood from the lungs is received, and it is here that myxomas are most likely to develop. This is due to the fact that myxomas often arise from the **interatrial septum**, particularly around the **fossa ovalis**.

**Why Each Wrong Option is Incorrect**
**Option A:** While it is true that the commonest site is the left atrium, this option does not directly answer the question as it is part of a larger statement about characteristics of cardiac myxoma.
**Option B:** Cardiac myxomas can recur after excision, especially if they are not completely removed.
**Option C:** Distant metastasis is not a characteristic of cardiac myxoma, as it is a benign tumor.

**Clinical Pearl / High-Yield Fact**
A key point to remember is that cardiac myxomas can mimic other cardiac conditions, such as **mitral stenosis**, due to their location and potential to obstruct blood flow.

**Correct Answer:** D. More common in females