Which of the following is true about TB meningitis-a) Exudates are formed on the convexities of brainb) CSF stored at 4°C in the time of transportationc) Hydrocephalus is common sequalaed) Meningoencephalitis is common manifestation
**Core Concept**
TB meningitis is a rare but serious form of tuberculosis that affects the meninges, the protective membranes surrounding the brain and spinal cord. It is characterized by inflammation of the meninges, leading to symptoms such as headache, fever, and altered mental status. The pathogenesis of TB meningitis involves the hematogenous spread of Mycobacterium tuberculosis to the meninges, where it causes a chronic, granulomatous inflammation.
**Why the Correct Answer is Right**
TB meningitis typically presents with a thick, gelatinous exudate that forms on the basal surfaces of the brain, not on the convexities. This is because the basal meninges are more susceptible to the effects of TB due to their rich blood supply and proximity to the infection site. The correct storage temperature of cerebrospinal fluid (CSF) at 4°C during transportation is crucial for preserving its integrity and allowing for accurate laboratory analysis. Hydrocephalus is a less common complication of TB meningitis, and meningoencephalitis is a manifestation of the disease, but not the most common one.
**Why Each Wrong Option is Incorrect**
**Option A:** Exudates are not typically formed on the convexities of the brain in TB meningitis, making this option incorrect.
**Option B:** While proper storage of CSF is essential, the statement that CSF stored at 4°C in the time of transportation is true, making this option partially correct, but the question asks for the most accurate statement about TB meningitis.
**Option C:** Hydrocephalus is not a common sequelae of TB meningitis, making this option incorrect.
**Option D:** Meningoencephalitis is a manifestation of TB meningitis, but not the most common one, making this option partially correct, but the question asks for the most accurate statement about TB meningitis.
**Clinical Pearl / High-Yield Fact**
TB meningitis often presents with a triad of symptoms: headache, fever, and altered mental status. Early diagnosis and treatment are crucial to prevent long-term neurological sequelae.
**Correct Answer:** D. Meningoencephalitis is a common manifestation