Virulence factors for meningococci ?
**Core Concept**
Meningococci are a type of Gram-negative bacteria that can cause meningitis and sepsis. Virulence factors are molecules produced by the bacteria that enable them to colonize and invade the host, evade the immune system, and produce disease. The main virulence factors for meningococci include the polysaccharide capsule, pili, and the outer membrane proteins.
**Why the Correct Answer is Right**
The polysaccharide capsule of Neisseria meningitidis is a key virulence factor that protects the bacteria from phagocytosis by neutrophils and macrophages. The capsule is composed of a polysaccharide called poly-N-acetylglucosamine (PNAG), which is produced by the enzyme PNAG synthase. The capsule is essential for the bacteria to adhere to and invade the epithelial cells of the nasopharynx, where they can colonize and eventually invade the bloodstream and central nervous system. The outer membrane proteins, such as Opa and Opc, also play a role in adherence and invasion.
**Why Each Wrong Option is Incorrect**
* **Option A:** While the pili of meningococci do play a role in adherence and colonization, they are not the primary virulence factor.
* **Option B:** The outer membrane proteins of meningococci are involved in adherence and invasion, but they are not the most important virulence factor.
* **Option C:** This option is incomplete and does not provide any information about a virulence factor.
**Clinical Pearl / High-Yield Fact**
The polysaccharide capsule of Neisseria meningitidis is the primary virulence factor that makes it a pathogen. The capsule is essential for the bacteria to evade the immune system and produce disease.
**Correct Answer:** C.