Drug used for prophylaxis of meningococcal meningitis: September 2008
## **Core Concept**
The question tests knowledge of chemoprophylaxis for meningococcal meningitis, a severe bacterial infection caused by *Neisseria meningitidis*. Effective prophylaxis is crucial for preventing outbreaks, especially in close-contact settings like schools or military barracks.
## **Why the Correct Answer is Right**
Ceftriaxone is a third-generation cephalosporin with potent activity against *Neisseria meningitidis*, making it an effective option for prophylaxis against meningococcal meningitis. A single dose of ceftriaxone has been shown to eradicate nasopharyngeal carriage of *N. meningitidis*, thereby reducing the risk of transmission. This property makes it particularly useful in outbreak situations or for individuals at high risk.
## **Why Each Wrong Option is Incorrect**
* **Option A:** Ciprofloxacin, a fluoroquinolone antibiotic, can be used for prophylaxis but is generally reserved for adults due to potential effects on cartilage development in children. It's not the first choice for broad application.
* **Option B:** Erythromycin is a macrolide antibiotic that is not effective against *N. meningitidis*, making it inappropriate for prophylaxis of meningococcal meningitis.
* **Option D:** Rifampicin (or rifampin) is indeed used for prophylaxis but can have significant drug interactions and side effects. While effective, the question's context points towards another commonly recommended option.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that chemoprophylaxis for meningococcal meningitis is recommended for close contacts of individuals with the disease, such as household members, daycare contacts, and healthcare workers with direct exposure. Ceftriaxone, given as a single dose, is particularly advantageous in these situations due to its efficacy and ease of administration.
## **Correct Answer:** . Ceftriaxone.