**Core Concept**
Tuberculous meningitis (TBM) is a severe form of central nervous system (CNS) tuberculosis, characterized by inflammation of the meninges due to Mycobacterium tuberculosis infection. The cerebrospinal fluid (CSF) analysis is crucial for diagnosing TBM, as it reflects the inflammatory response and bacterial invasion.

**Why the Correct Answer is Right**
In TBM, the CSF typically shows a decrease in glucose levels (hypoglycorrhachia) due to bacterial glycolysis and impaired glucose transport across the blood-brain barrier. The protein levels are elevated in response to the breakdown of the blood-brain barrier and the release of inflammatory mediators. Lymphocytosis, or an increase in lymphocytes, is a hallmark of TBM, indicating an immune response to the bacterial infection. This combination of low glucose, high protein, and lymphocytosis is a classic CSF profile in TBM.

**Why Each Wrong Option is Incorrect**
**Option A:** High sugar + low protein is incorrect because TBM typically presents with low glucose levels and elevated protein levels.
**Option C:** High sugar + high chloride is incorrect because TBM is characterized by low glucose levels, not high, and chloride levels are often decreased due to impaired CSF production.
**Option D:** Low sugar + high protein and Lymphopenia is incorrect because TBM typically shows lymphocytosis, not lymphopenia, indicating an active immune response.

**Clinical Pearl / High-Yield Fact**
In TBM, the CSF glucose level is inversely correlated with the severity of the disease. A CSF glucose level of less than 2.5 mmol/L is often associated with a poor prognosis and increased mortality.

**✓ Correct Answer: B. Low sugar + high protein and Lymphocytosis**