**Question:** Megalocornea is associated with A/E -

A. Glaucoma
B. Keratoconus
C. Primary open angle glaucoma
D. Fuchs' dystrophy

**Correct Answer:** D. Fuchs' dystrophy

**Core Concept:** Megalocornea is an ocular condition characterized by abnormally large corneas, which can lead to increased exposure and irritation of the corneal surface, and may be associated with various ocular conditions.

**Why the Correct Answer is Right:** Fuchs' dystrophy is a degenerative corneal disease characterized by the breakdown and thinning of the corneal endothelial cells, leading to corneal edema and visual impairment. In this context, the large corneas seen in megalocornea are a result of corneal edema, which is a common feature of Fuchs' dystrophy.

**Why Each Wrong Option is Incorrect:**

A. Glaucoma: This option refers to a group of eye conditions characterized by elevated intraocular pressure, which may lead to optic neuropathy and vision loss. Glaucoma is not directly associated with megalocornea.

B. Keratoconus: Keratoconus is a degenerative corneal disease characterized by progressive thinning and cone-shaped bulging of the cornea, leading to visual impairment. Unlike Fuchs' dystrophy, keratoconus is not associated with large corneas.

C. Primary open angle glaucoma: This refers to a type of glaucoma characterized by elevated intraocular pressure, which may lead to optic neuropathy and vision loss. Primary open angle glaucoma is not directly associated with megalocornea.

**Clinical Pearl:** The association of megalocornea with Fuchs' dystrophy highlights the importance of a thorough ophthalmological evaluation in patients presenting with large corneas, to rule out underlying ocular conditions requiring appropriate management.