Folate deficiency can occur from a number of etiologies including poor intake or absorption; in high-demand diseases such as sickle cell; and in inborn errors of metabolism. It can also be seen in conjunction with a variety of medication uses including high-dose nonsteroidal anti-inflammatory drugs (NSAIDs), methotrexate, and phenytoin. Deficiency results in megaloblastic anemia, glossitis, pharyngeal ulcers, and impaired immunity.