Mediator of acute inflammation not derived from the cell is:
Correct Answer: Kinins
Description: CHEMICAL MEDIATORS OF INFLAMMATION
Aka permeability factors or endogenous mediators of increased vascular permeability.
They are broadly classified into 2 groups:
i. Mediators released by cells.
ii. Mediators originating from plasma.
CHEMICAL MEDIATORS OF ACUTE INFLAMMATION
A. Cell-Derived Mediators
1. Vasoactive amines
Histamine.
5-hydroxytryptamine.
Neuropeptides.
2. Arachidonic acid metabolites (Eicosanoids)
i. Metabolites via the cyclo-oxygenase pathway
Prostaglandins.
Thromboxane A2.
Prostacyclin.
Resolvins.
ii. Metabolites via a lipo-oxygenase pathway
5-HETE.
Leukotrienes.
Lipoxins.
3. Lysosomal components (from PM Ms, macrophages)
4. Platelet-activating factor (PAF)
5. Cytokines
IL-1
TNF-α.
TNF-β.
IFN-γ.
Chemokines.
6. Free radicals
Oxygen metabolites
Nitric oxide
B. Plasma-Derived Mediators (Plasma Proteases)
Products of:
1. The kinin system.
2. The Clotting system.
3. The Fibrinolytic system.
4. The Complement system.
Category:
Pathology
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