**Core Concept**
Meconium ileus is a condition where the small intestine of a newborn becomes obstructed due to a thick, tar-like meconium that fails to pass through the intestinal tract. This condition is often associated with cystic fibrosis, a genetic disorder that affects the production of mucus in the body.

**Why the Correct Answer is Right**
The primary treatment for meconium ileus involves the administration of a hyperosmolar solution to help break down the thick meconium and facilitate its passage through the intestinal tract. Gastrografin (a type of contrast agent) is often used to help dissolve the meconium and restore intestinal patency. This treatment approach is based on the principle of using a hyperosmolar solution to disrupt the water content of the meconium, making it softer and more easily passable.

**Why Each Wrong Option is Incorrect**
**Option A:** Enemas may be used in some cases, but they are not the primary treatment for meconium ileus.
**Option B:** Antibiotics are not the primary treatment for meconium ileus, as the condition is caused by a physical obstruction rather than a bacterial infection.
**Option C:** Surgery may be necessary in some cases, but it is not the initial treatment of choice for meconium ileus.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that meconium ileus is often a presenting feature of cystic fibrosis, a genetic disorder that affects the production of mucus in the body.

**Correct Answer:** C. Gastrografin administration.