Mechanism of digitalis in atrial fibrillation:
Correct Answer: Increase refractoriness of AV node
Description: Ans. C. Increase refractoriness of AV nodeDigoxin is inotropic agent used in heart failure. It has positive inotropic effect and negative chronotropic effect. Inotropic effect is due to blockade of Na+K+ATPase pump. Chronotropic effect is due to vagomimetic effect which increase the refractoriness of AV node. This mechanism is utilized in atrial flutter and fibrillation. Answer is C
Category:
Pharmacology
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