Mechanism of action of pertussis toxin is all except:
Correct Answer: Act by ADP ribosylation of GI subunit
Description: Ans. is 'a' i.e., Act by ADP ribosylation of GI subunitRef: (Harrison, 19th/e, p. 1021 and Ananthanarayan, 9th/e, p. 333)Pertussis toxin (PT) - Most imp. Virulence factor composed of 2 subunits (A and B) like cholera toxin. A subunit having ADP ribosylation activity of G protein - | cAMP - responsible for several biological effects like T cell mitogeni- city, Hemagglutination, Adhesion to respiratory ciliated cells, induction of leukocytosis, histamine sensitizer.
Category:
Microbiology
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