**Core Concept**
Paclitaxel is a chemotherapeutic agent that belongs to the class of taxanes. It stabilizes microtubules by binding to tubulin, thereby inhibiting cell division and leading to apoptosis in rapidly dividing cancer cells.
**Why the Correct Answer is Right**
Paclitaxel exerts its effect by binding to the beta subunit of tubulin, which prevents the disassembly of microtubules. This stabilization of microtubules inhibits the normal dynamic behavior of microtubules, leading to the accumulation of microtubules in the mitotic spindle. As a result, cells are unable to undergo mitosis, and apoptosis is induced. This mechanism of action is specific to rapidly dividing cells, making paclitaxel an effective chemotherapeutic agent for treating various types of cancer.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not provided, so we will not address it.
* **Option B:** Paclitaxel does not work by inhibiting topoisomerase enzymes, which are the target of anthracycline antibiotics like doxorubicin.
* **Option C:** Paclitaxel does not work by inhibiting tubulin polymerization, which is the mechanism of action of vinca alkaloids like vincristine.
**Clinical Pearl / High-Yield Fact**
Paclitaxel is often administered in combination with other chemotherapeutic agents, such as carboplatin, to enhance its effectiveness and reduce the risk of resistance.
**Correct Answer: C. Paclitaxel stabilizes microtubules by binding to tubulin.**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.