Mechanism of action of Clonidine in opioid withdrawal syndrome is
Correct Answer: Action on a2 presynaptic nerve ending
Description: Ans. is 'c' i.e., Action on a2 presynaptic nerve ending Many of the symptoms of opioid withdrawl such as nausea, vomiting, cramps, sweating, tachycardia, and hypertension are a result of loss of opioid suppression of locus ceruleus system during abstinence syndrome. Clonidine is an a2 agonist that reduces adrenergic transmission from locus ceruleus.Clonidine acts on these a2 receptors and supress adrenergic activity in locus ceruleus. (Thus mimicking the action of opioids).In this way it alleviates mainly the autonomic symptoms of opioid withdrawl.Non autonomic symptoms of opioid withdrawl are not affected.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now