Mechanism of action colchicine in acute gout
Correct Answer: Deficiency of enzyme Xanthine oxidase
Description: * Gout is a hereditary disorder with increase in serum uric acid due to increased production, or decreased excretion of uric acid and uric salt. * Thought to be caused by lack of an enzyme needed to completely metabolise purines for renal excretion. REF : HARRISONS 21ST ED
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