**Core Concept**
Amoxapine is a tricyclic antidepressant (TCA) that acts primarily as a norepinephrine-dopamine antagonist, although it also exhibits some serotonin reuptake inhibition properties. This unique mechanism of action contributes to its therapeutic efficacy in treating major depressive disorder.

**Why the Correct Answer is Right**
Amoxapine primarily exerts its antidepressant effects by blocking the reuptake of norepinephrine and dopamine, thereby increasing the concentration of these neurotransmitters in the synaptic cleft. This action is mediated through its ability to antagonize the presynaptic alpha-2 adrenergic receptors, which are responsible for regulating the release of norepinephrine. As a result, amoxapine increases the availability of norepinephrine and dopamine for postsynaptic receptors, leading to improved mood and reduced symptoms of depression.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not accurately describe the primary mechanism of action of amoxapine.
* **Option B:** This option is incorrect because amoxapine is not primarily a serotonin reuptake inhibitor; while it does exhibit some serotonin reuptake inhibition properties, its norepinephrine-dopamine antagonist action is more significant.
* **Option D:** This option is incorrect because amoxapine does not primarily act as a selective serotonin reuptake inhibitor (SSRI).

**Clinical Pearl / High-Yield Fact**
Amoxapine's unique mechanism of action as a norepinephrine-dopamine antagonist makes it a useful treatment option for patients with major depressive disorder who have not responded to traditional SSRIs or other antidepressant therapies. However, its use is limited due to its potential for causing extrapyramidal side effects, such as dystonia and parkinsonism.

**Correct Answer:** C.