**Core Concept**
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a condition where there is an excessive release of antidiuretic hormone (ADH), also known as vasopressin, leading to water retention and hyponatremia. This condition is characterized by the inappropriate secretion of ADH in the presence of normal or low plasma osmolality.
**Why the Correct Answer is Right**
In SIADH, the excessive release of ADH causes the kidneys to retain water, resulting in dilutional hyponatremia. The mechanism involves the ADH-stimulated water reabsorption in the collecting ducts of the kidneys, which increases the water content of the blood and decreases the sodium concentration. The pathophysiology of SIADH is complex and can be triggered by various factors, including malignancies, infections, and certain medications.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because SIADH is not primarily associated with hypernatremia. In fact, the hallmark of SIADH is dilutional hyponatremia.
* **Option B:** This option is incorrect because SIADH is not characterized by an inability to concentrate urine. Instead, the kidneys are over-sensitive to ADH, leading to excessive water reabsorption and dilute urine.
* **Option C:** This option is incorrect because SIADH is not primarily associated with hypovolemia. In fact, patients with SIADH often have normal or increased plasma volume.
**Clinical Pearl / High-Yield Fact**
A key feature of SIADH is the presence of hyponatremia in the absence of volume depletion or cardiac failure. This is often referred to as the "euvolemic" form of hyponatremia.
**Correct Answer:** C.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.