**Core Concept:** The question is testing the knowledge of viral infections and their characteristic features, which include inclusion bodies. Inclusion bodies are abnormal accumulations of cellular components within the cell, often seen in electron microscopy. In this context, intranuclear inclusion bodies refer to inclusion bodies located within the nucleus, while intracytoplasmic inclusion bodies are located within the cytoplasm.
**Why the Correct Answer is Right:** The correct answer, **D. Coxsackievirus**, is a member of the Enterovirus genus within the Picornaviridae family. When coxsackievirus infects cells, it produces two types of inclusion bodies: intranuclear and intracytoplasmic. Intranuclear inclusions are formed due to the accumulation of viral RNA and protein in the nucleus, while intracytoplasmic inclusions are formed due to the accumulation of viral proteins in the cytoplasm.
**Why Each Wrong Option is Incorrect:**
A. **Polio virus** belongs to the Picornaviridae family and is known for producing intranuclear inclusion bodies only.
B. **Influenza virus** belongs to the Orthomyxoviridae family and typically produces intracytoplasmic inclusion bodies known as hemagglutinin-neuraminidase inclusions.
C. **Measles virus** belongs to the Morbillivirus family and typically produces intranuclear inclusion bodies called Reed-Munchow bodies.
**Why the Correct Answer is Right:** The correct answer, **D. Coxsackievirus**, is known to produce both intranuclear and intracytoplasmic inclusion bodies, making it the correct choice.
**Clinical Pearl:** Infectious diseases caused by enteroviruses, like coxsackievirus, can present with characteristic inclusion bodies in the affected organs. These findings help in the diagnosis of the disease, particularly when clinical symptoms are not specific.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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