The expression of the following oncogene is associated with a high incidence of Medullary carcinoma of thyroid –
**Core Concept**
Medullary carcinoma of the thyroid (MTC) is a type of thyroid cancer originating from the parafollicular cells (C-cells) that produce calcitonin. The expression of a specific oncogene is linked to the development of MTC.
**Why the Correct Answer is Right**
The RET proto-oncogene is a key player in the pathogenesis of MTC. RET mutations lead to the constitutive activation of the tyrosine kinase domain, resulting in uncontrolled cell proliferation and tumor formation. The RET proto-oncogene is a receptor tyrosine kinase that, when mutated, can cause the development of MTC. This is because the mutated RET protein can lead to the activation of downstream signaling pathways that promote cell growth and survival.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the BRAF V600E mutation is associated with papillary thyroid carcinoma, not MTC.
**Option B:** This option is incorrect because the RAS oncogene is involved in various types of cancer, but it is not specifically associated with MTC.
**Option C:** This option is incorrect because the HER2 oncogene is associated with breast cancer and some other types of cancer, but it is not linked to MTC.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that the RET proto-oncogene is linked to familial MTC, and genetic testing for RET mutations can help identify individuals at risk for developing this condition.
**Correct Answer: C. RET proto-oncogene**