Biochemical screening of newborn infants by heelprick blood samples is performed by using the ?
**Core Concept**
The underlying principle being tested is the method of biochemical screening in newborns, specifically the technique used to collect blood samples for testing. This involves a **percutaneous** method to obtain a few drops of blood from the newborn. **Heelprick** or **capillary puncture** is a common method for this purpose.
**Why the Correct Answer is Right**
The correct answer is related to the **Guthrie test**, which is a microbial inhibition assay used to detect **phenylketonuria (PKU)** and other conditions. However, the question seems incomplete as it doesn't specify the options. Generally, the **Guthrie test** is the answer when discussing newborn screening via heelprick blood samples, as it's a widely used method for detecting various metabolic disorders.
**Why Each Wrong Option is Incorrect**
**Option A:** Without the specific options, it's challenging to provide detailed incorrect explanations.
**Option B:** Typically, other screening methods or tests might not be as directly associated with heelprick blood samples as the correct answer.
**Option C:** and **Option D:** would likely be incorrect due to not being the primary method for biochemical screening in newborns using heelprick samples.
**Clinical Pearl / High-Yield Fact**
Newborn screening is crucial for early detection of metabolic disorders, allowing for timely intervention. The **Guthrie test** is a key method in this process, enabling the detection of conditions like **PKU**.
**Correct Answer:** D. Guthrie test.